Literature is not just the reflection of the broader society and a messenger for a better future. It is also about a deep catharsis for the human soul. Covid-19 showed our vulnerability, helplessness and at the same time solidarity to fight it together. Time did not stop nor did the lived human experience. To celebrate this spirit of life KLF 2021 is here to engage with thought provoking ideas and the resilient human spirit. Apart from several dedicated sessions on contemporary debates and discourses in the public sphere, the newly launched KLF Book Awards will add significant value to spread ideas while at the same time intends to redefine and contribute to the Literary Culture of India and the world.
Despite having a very rapid rate of evolution over short timescales, to survive, viruses must remain highly adapted to their hosts – this imposes severe restrictions on their freedom to accumulate mutations without reducing their fitness. This causes the apparent rate of evolution of viruses to slow down over time. The new research, for the first time, successfully recreates the patterns of this observed rate decay in viruses.
‘We developed a new method that can recover the age of viruses over longer timescales and correct for a kind of ‘evolutionary relativity’, where the apparent rate of evolution depends on the timescale of measurement. Our estimate based on viral sequence data, of more than 21,000 years ago, is in remarkable concordance with a recent analysis on human genomic dataset that suggests infection with an ancient coronavirus around the same time.’ Said Mahan Ghafari, from Oxford University.
The study also demonstrates that while existing evolutionary models have often failed to measure the divergence between virus species over periods – from a few hundred to a few thousands of years – the evolutionary framework developed in this study will enable the reliable estimation of virus divergence across vast timescales, potentially over the entire course of animal and plant evolution.
The new model enables us to not only reconstruct the evolutionary history of viruses related to SARS-CoV-2, but also a much wider range of RNA and DNA viruses during more remote periods in the past.
The model predictions for hepatitis C virus – a leading global cause of liver disease – are consistent with the idea that it has circulated for nearly a half a million years. HCV may thus have spread worldwide as an intrinsic part of the “Out-of-Africa” migration of modern humans around 150,000 years ago.
The different genotypes of HCV indigenous to human populations in South and South-East Asia and Central Africa may have originated over this prolonged period and this revised timescale may resolve the longstanding riddle of their global distributions.
‘With this new technique we can look much more widely at other viruses; re-evaluate the timescales of their deeper evolution and gain insights into host relationships that are key to understanding their ability to cause disease.’ Prof Simmonds, Oxford University
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