Is ZINC helpful in Depression ?


Is ZINC helpful in Depression ? This question was asked by one of the respondents of ‘Ask for Zinc’. The answer is YES….. it turns out that Zinc plays a part in modulating the brain and body’s response to stress all along the way…


Zinc has been found to be low in the serum of those suffering from depression. In fact, the lower the Zinc level, the more depressed a person is. Zinc deficiency can lead to symptoms of depression, difficulties with learning and memory, seizures, aggression, and violence.


Low serotonin levels are also believed to be the cause of many cases of mild to severe depression which can lead to symptoms such as anxiety, apathy, fear, feelings of worthlessness, insomnia and fatigue. The enzymes containing Zinc are necessary for the synthesis of serotonin.


Since the 1920s Zinc has been known to play a credible role in mental health. Decades of research have found a link between taking Zinc supplements and improvement in the symptoms of schizophrenia, autism, ADHD (Attention Deficit Hyperactivity Disorder) and other mental health problems.


Around 300 enzymes in our bodies use Zinc to help make DNA, for protein synthesis, cell division, cell growth etc. Zinc is particularly found in a part of the brain called the hippocampus.


In the hippocampus, which is the part of the brain central to memory and mood, antidepressants work by increasing the production of the nerve fertilizer BDNF (Brain-Derived Neurotrophic Factor) in the hippocampus, which helps in nerve recovery, adaptation, and repair. Zinc deficiency leads to decreased Zinc in the nerve synapse. The same mechanism might be responsible for seizures, migraines, dementia, anxiety, depression, and bipolar disorder.


Under conditions of major stress, Zinc swiftly leaves the body in the form of urine, sweat, and saliva. A daily intake of Zinc is required to maintain a steady state of the body.


Hindustan Zinc is India’s only and world’s leading Zinc-Lead-Silver Producer..

Article by- Pavan Kaushik, Head – Corporate Communication, Hindustan Zinc


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